Poster Details
PHARMACEUTICAL UPTAKE KINETICS IN RAINBOW TROUT FROM EAST CANYON CREEK, AN EFFLUENT-DOMINATED STREAM INFLUENCED BY SNOWMELT IN PARK CITY, UTAH, USA
Whether seasonal instream flow dynamics influence uptake of select pharmaceuticals by fish is not well understood, specifically for urban lotic systems in semi-arid regions with flows influenced by snowmelt. We examined uptake of select pharmaceuticals in rainbow trout (Oncorhynchus mykiss) caged upstream and at incremental distances downstream (0.15, 1.4, 13 miles) from a municipal effluent discharge to East Canyon Creek in Park City, Utah, USA during summer and fall of 2018. Fish were sampled over 7-d to define uptake kinetics. Water and fish tissues were analyzed via isotope dilution LC-MSMS. Several pharmaceuticals were consistently detected in water, fish tissue and plasma, including diphenhydramine, carbamazepine, fluoxetine, and norfluoxetine. Pharmaceutical levels in water ranged up to 151 ng/L for carbamazepine, whereas the effluent tracer sucralose was consistently observed at low ug/L levels. During both summer and fall experiments at each of three downstream locations from effluent discharge, rainbow trout rapidly accumulated these pharmaceuticals; tissue levels reached steady state conditions within 24 – 96 hrs. Such observations are consistent with our recent laboratory bioconcentration studies, which collectively indicate inhalational exposure from water governs rapid pharmaceutical accumulation by fish in inland surface waters.
Jaylen Sims (Primary Presenter/Author), Baylor University, jaylen_sims1@baylor.edu;
S. Rebekah Burket (Co-Presenter/Co-Author), Baylor University, bekah_burket@baylor.edu;
Marco Franco (Co-Presenter/Co-Author), Baylor University, marco_franco1@baylor.edu;
Lea Lovin (Co-Presenter/Co-Author), Baylor University, lea_lovin1@baylor.edu;
Kendall Scarlett (Co-Presenter/Co-Author), Baylor University, kendall_scarlett1@baylor.edu;
Ruud Steenbeek (Co-Presenter/Co-Author), Baylor University, ruud_steenbeek@baylor.edu;
Craig Aschcroft (Co-Presenter/Co-Author), Carollo Engineers, cashcroft@carollo.com;
Michael Luers (Co-Presenter/Co-Author), Snyderville Basin Water Reclamation District, mluers@sbwrd.org;
Ramon Lavado (Co-Presenter/Co-Author), Baylor University, ramon_lavado@baylor.edu;
Bryan Brooks (Co-Presenter/Co-Author), Baylor University, bryan_brooks@baylor.edu;